Yuanming Li, Fan Jia and Prof. Dr. Zhiping Li
Volume 19, Issue 1, pages 82–86, January 2, 2013
Article first published online: 3 DEC 2012 | DOI: 10.1002/chem.201203824
Unconventional couple: A new oxidative coupling protocol for amide bond formation has been developed (see scheme). The method provides an efficient and practical route for the synthesis of tertiary amides from readily available tertiary amines and aldehydes in the presence of a simple FeCl2catalyst. Mechanistic studies indicated that a peroxide and an iminium ion act as the reactive intermediates in this oxidative amidation.