Sulforaphane, a natural product present in cruciferous vegetables like broccoli, reduces childhood leukemia progression


Sulforaphane
1-Isothiocyanato-4-methylsulfinylbutane
Sulforaphane is a molecule, ref1 within the isothiocyanate group of organosulfur compounds. It exhibits anti-cancer and antimicrobial properties in experimental models. It is obtained from cruciferous vegetables such as broccoliBrussels sprouts or cabbages. It is produced when the enzyme myrosinase transforms glucoraphanin, a glucosinolate, into sulforaphane upon damage to the plant (such as from chewing) which allows the two compounds to mix and react. Young sprouts of broccoli and cauliflower are particularly rich in glucoraphanin.
Glucoraphanin.png
glucoraphanin, glucosinolate precursor to sulforaphane
Sulforaphane, discovered by accident in 1995 by a group of scientists researching the anticancer compounds in broccoli, is a phytochemical compound that can be obtained by eating cruciferous vegetables such as arugula, watercress, Brussels sprouts, broccoli, broccoli sprouts, cabbage, cauliflower, bok choy, kale, collards, kohlrabi, mustard, turnip, radish and rutabaga.  Sulforaphane is particularly abundant in watercress and broccoli sprouts.

Sulforaphane, a natural product present in cruciferous vegetables like broccoli, reduces childhood leukemia progression

article
Sulforaphane Induces Cell Cycle Arrest and Apoptosis in Acute Lymphoblastic Leukemia Cells,
K. Suppipat, C. Shik Park, Y. Shen, X. Zhu, H. D. Lacorazza, 
PLOS ONE 2012.
DOI: 10.1371/journal.pone.0051251


 Related topics


click on above link

Sulforaphane is a phytochemical belonging to the family of isothiocyanates, which means it contains the typical NCS group.
Sulforaphane was identified in broccoli sprouts, which, of the cruciferous vegetables, have the highest concentration of sulforaphane. It is also found in Brussels sproutscabbage,cauliflowerbok choykalecollardsChinese broccolibroccoli raabkohlrabimustard,turnipradisharugula, and watercress
The optimal level of intake is not known, but some doctors recommend 200 to 400 mcg of sulforaphane daily from broccoli-sprout extracts.
Acute lymphoblastic leukemia is the most common form of blood cancer affecting children. Although the current treatments cure 8 % of the patients, in the remaining cases the disease recurs and it can be fatal. Thus, novel drugs effective against relapses are needed.

To this regard, Koramit Suppipat, Texas Children’s Hospital, USA, and colleagues investigated the anti leukemic properties of sulforaphane, a dietary isothiocyanate abundant in cruciferous vegetables, such as broccoli. This compound blocked the proliferation of pediatric leukemic cells and selectively promoted their death, mostly by inhibiting Akt and mTOR, two serine/threonine kinases necessary for the survival of these malignant cells. When administered orally to mice affected by leukemia, moreover, sulforaphane reduced the progression of the tumor.
This compound may thus be beneficial for acute lymphoblastic leukemia patients at high risk of relapse.
We know that stress accelerates aging and disease.  When you are under stress, your immune system is also compromised, weakening your ability to ward off invading organisms.  Chronic stress raises the level of the excitatory hormones, including norepinephrine and cortisol, which can wear your body down and lead to disease.  Sulforaphane inhibits the norepinephrine-mediated increase in the interleukin-6 levels in the cells, which is a very good thing.  Interleukin-6 is responsible for the shift from acute inflammation to chronic inflammation, the root of so many diseases.  Finding a safe and effective substance that can inhibit the overproduction of norepinephrine, like sulforaphane,  is a significant accomplishment.
Consumption of broccoli sprouts has shown to be potentially effective at inhibitingHelicobacter pylori growth,[2][3] with sulforaphane being at least one of the active agents.[4][2]
Sulforaphane and dietary consumption of cruciferous vegetables are known to affect the action of drug-metabolizing enzymes in vitroand in preliminary human studies.[5] Although no side effects or direct drug interactions have been reported as of 2008, people taking prescription drugs are advised to consult a doctor before taking sulforaphane or broccoli-sprout extracts.
The possible anticancer activity of sulforaphane may be related to the induction of phase-II enzymes of xenobiotic transformation (such as quinone reductase and glutathione S-transferase), and enhancing the transcription of tumor suppressor proteins, possibly via inhibitory effects on histone deacetylase.[6]
Sulforaphane and diindolylmethane (another compound from Brassica vegetables) inhibit cancer growth in vitro and in experimental animals.[7] Sulforaphane downregulated the Wnt/beta-catenin self-renewal pathway in breast cancer stem cells.[7]


Sulforaphane

Sulforaphane

MW: 177
Formula: C6H11NOS2

Linkslinks

  1. Zhang Y, Talalay P, Cho CG, Posner GH (March 1992). "A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure"Proc. Natl. Acad. Sci. U.S.A. 89 (6): 2399–2403. doi:10.1073/pnas.89.6.2399PMC 48665.PMID 1549603.
  2. Yanaka A, Fahey JW, Fukumoto A, Nakayama M, Inoue S, Zhang S, Tauchi M, Suzuki H, Hyodo I, Yamamoto M (April 2009). "Dietary sulforaphane-rich broccoli sprouts reduce colonization and attenuate gastritis in Helicobacter pylori–infected mice and humans". Cancer Prev. Res. 2 (4): 353–360. doi:10.1158/1940-6207.CAPR-08-0192PMID 19349290Lay summary.
  3. Galan MV, Kishan AA, Silverman AL (August 2004). "Oral broccoli sprouts for the treatment of Helicobacter pylori infection: a preliminary report". Dig Dis Sci. 49 (7–8): 1088–1090. doi:10.1023/B:DDAS.0000037792.04787.8aPMID 15387326.
  4. Fahey JW, Haristoy X, Dolan PM et al. (May 2002). "Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors"Proc. Natl. Acad. Sci. U.S.A. 99 (11): 7610–7615.doi:10.1073/pnas.112203099PMC 124299PMID 12032331.
  5. Kall MA, Vang O, Clausen J (March 1997). "Effects of dietary broccoli on human drug metabolising activity". Cancer Lett. 114 (1–2): 169–170. doi:10.1016/S0304-3835(97)04652-1PMID 9103281.
  6. Hayes, JD; Kelleher, MO; Eggleston, IM (2008). "The cancer chemopreventive actions of phytochemicals derived from glucosinolates".European Journal of Nutrition 47 Suppl 2: 73–88. doi:10.1007/s00394-008-2009-8PMID 18458837.
  7. Li et al. (May 2010). "Sulforaphane, a dietary component of broccoli/broccoli sprouts, inhibits breast cancer stem cells"Clinical Cancer Research 16 (9): 2580–2590. doi:10.1158/1078-0432.CCR-09-2937PMC 2862133PMID 20388854.



read about synthesis
[PDF] 

A Facile and Green Synthesis of Sulforaphane

imm.ac.cn/journal/ccl/1709/170905-1152-c060185-p3.pdf
File Format: PDF/Adobe Acrobat - Quick View
by D Tong Jian - 2006 - Cited by 3 - Related articles
A Facile and Green Synthesis of Sulforaphane. Tong Jian DING, Ling ZHOU, Xiao Ping CAO*. Sate Key Laboratory of Applied Organic Chemistry and College of ...

Write a comment

Comments: 47
  • #1

    Masticating Juicer (Wednesday, 10 April 2013 01:49)

    This post was in fact precisely what I was looking for!

  • #2

    leukemia causes (Wednesday, 11 September 2013 22:20)

    Leukemia can affect people at any age. In 2000 approximately 256,000 children and adults around the world developed some form of leukemia, and 209,000 died from it.

  • #3

    Obat untuk Penyakit Dispepsia (Monday, 14 September 2015 22:25)

    article you create satisfying enough for me, hopefully more inspiring in the future, do not forget to also see my site

  • #4

    Cara mengobati infeksi rubella pada ibu hamil (Tuesday, 22 September 2015 22:24)

    thank you for sharing the information that interests us all, may be beneficial

  • #5

    Pentingnya minyak ikan untuk mengurangi resiko penyakit (Thursday, 24 September 2015 22:31)

    we thank you very much to those of you who are already taking the time for the making of this article, so as to be useful for all of us

  • #6

    Obat Eksim pada Balita yang Alami dan Aman (Monday, 28 September 2015 01:29)

    article that you create a very inspiring and as our solution solves the problem

  • #7

    Cara Menghaluskan Kaki yang Pecah Pecah (Monday, 28 September 2015 22:09)

    we are expecting the next post can be loaded in detail in order to add aesthetics to the reader, but this time the articles I've read can also inspire me and add science to me

  • #8

    Obat Kulit Berair dan Ruam Merah di Tubuh (Tuesday, 29 September 2015 23:36)

    article that you created quite so help me solve the problem, thank you for sharing to us all

  • #9

    Cara Cepat Menurunkan Trigliserida yang Meningkat (Thursday, 01 October 2015 04:20)

    Thank you for sharing the information very interesting, do not forget to click also our article, hopefully useful

  • #10

    Cara Mengobati Gatal Eksim di Selangkangan (Thursday, 08 October 2015 02:42)

    I think your article is pretty good and really helped me in solving a problem, continue to increase again, and do not forget to visit our website :)

  • #11

    Cara Menyembuhkan Luka Caesar dengan Bahan Alami (Friday, 09 October 2015 21:56)

    posts that you make pretty good and I can understand it, continues to increase again, good luck brother, do not forget to visit my website too, thank you ^ - ^

  • #12

    Obat Tradisional Cacingan pada Anak (Sunday, 11 October 2015 21:47)

    articles you post that you make can greatly help me in solving a problem, continue to increase again

  • #13

    Obat Di Apotik (Friday, 16 October 2015 03:50)

    thank you post articles that are very useful for me, hopefully in the future, better yet, do not forget to visit my site

  • #14

    Obat penyakit jengger ayam pada wanita (Monday, 30 November 2015 00:05)

    I think that you post the article very useful to all who read it, do not forget to read our article Also

  • #15

    Obat yang aman untuk menghilangkan psoriasis pada ibu hamil (Friday, 11 December 2015 22:33)

    thank you for visiting our website, your article is also very useful for us.

  • #16

    Cara mengatasi nyeri kanker payudara stadium 1 (Wednesday, 23 December 2015 00:35)

    visit our website, help in sharing, thank you

  • #17

    Obat buah pelir kiri besar sebelah yang alami (Saturday, 26 December 2015 00:39)

    thank you for visiting our website, may be useful and do not forget to help share

  • #18

    Cara cepat mengobati jumlah sel darah putih yang naik (Saturday, 09 January 2016 02:01)

    thanks for his attentions, we like you article, don't forget share this article to other

  • #19

    quality wordpress themes (Saturday, 16 July 2016 07:15)

    A great website with interesting and unique material what else would you need.

  • #20

    $1 Web Hosting (Tuesday, 16 August 2016 04:11)

    Looking for Unlimited Space + Free Domain + Free website builder? Well, just purchase 1 Dollar Hosting services from MyTrueHost Australia and enjoy everything you expected to have. More details can be obtained from http://www.mytruehost.com

  • #21

    Cara Alami mengatasi Ejakulasi dini Pria Secara Herbal (Wednesday, 31 August 2016 21:05)

    News in your website is very helpful kami..sukses always everything !!!

  • #22

    psychic phone readings (Monday, 14 November 2016 06:37)

    ingested

  • #23

    sekstelefony (Monday, 14 November 2016 09:56)

    hussy

  • #24

    sex przez telefon (Monday, 14 November 2016 12:50)

    maximality

  • #25

    Liebeszauber (Tuesday, 15 November 2016 11:17)

    participates

  • #26

    namiętny sex telefon (Wednesday, 16 November 2016 02:47)

    hojniejszy

  • #27

    tutaj (Wednesday, 16 November 2016 07:53)

    ilota

  • #28

    miłosne zaklęcie (Thursday, 17 November 2016 05:39)

    Jaunde

  • #29

    seks ogłoszenia (Thursday, 17 November 2016 13:38)

    przecwałowawszy

  • #30

    źródło (Thursday, 24 November 2016 22:02)

    neołaciński

  • #31

    seks telefon (Tuesday, 29 November 2016 12:06)

    przewinienie

  • #32

    love spell (Wednesday, 30 November 2016 08:51)

    nieopielający

  • #33

    seks telefony (Tuesday, 06 December 2016 09:05)

    niewpompowujący

  • #34

    psychic readings (Wednesday, 14 December 2016 17:15)

    alliteration

  • #35

    sex telefon 24/7 (Monday, 19 December 2016 13:32)

    fellowships

  • #36

    heroin addiction treatment (Friday, 23 December 2016 03:24)

    I think this is a really good article. You make this information interesting and engaging. You give readers a lot to think about and I appreciate that kind of writing.

  • #37

    seks telefony (Monday, 16 January 2017 08:47)

    bieliźniarstwo

  • #38

    love spell (Friday, 20 January 2017 06:18)

    paroksytonizm

  • #39

    asas (Saturday, 04 February 2017)

    asda

  • #40

    rytuał miłosny (Monday, 10 April 2017 04:35)

    rytuał miłosny

  • #41

    best Skin Growth formula (Saturday, 24 June 2017 03:12)

    Pretty good post. I just stumbled upon your blog and wanted to say that I have really enjoyed reading your blog posts. Any way I'll be subscribing to your feed and I hope you post again soon. Big thanks for the useful info.

  • #42

    Falafel Wrap in USA (Sunday, 06 August 2017 17:12)

    Your music is amazing. You have some very talented artists. I wish you the best of success.

  • #43

    sex dziwki (Monday, 04 September 2017 12:16)

    gestagen

  • #44

    seks w okolicy (Friday, 08 September 2017 09:07)

    łużycki

  • #45

    sex dziwki na telefon (Saturday, 09 September 2017 04:58)

    podżarłyby

  • #46

    sexphone.pl (Saturday, 09 September 2017 08:13)

    nadwyrężyć

  • #47

    wróżka telefoniczna (Thursday, 14 September 2017 06:01)

    niedepersonalizowanie

Comments: 3
  • #3

    Obat alami supaya gairah berhubungan seksual (Sunday, 16 October 2016 23:28)

    articles were awesome and very helpful, thank you very much

  • #2

    Cara Pemesanan Glucoblock (Saturday, 24 September 2016 04:13)

    Terimakasih Informasinya, sangat menarik dan bermanfaat :D.
    http://carapemesananglucoblock.wordpress.com/
    http://carapemesanannutrimax.wordpress.com/
    http://carapemesananslimming.wordpress.com/

  • #1

    Obat kuat pria tahan lama (Tuesday, 06 September 2016 03:39)

    Semoga sukses selalu

Wed

25

Jan

2012

Organic Chemistry websites by Dr Anthony Melvin Crasto

WELCOME TO MY SITE ON JIMDO

These sites are on varied topics of organic chemistry

 

click belowto get to my collection of sites 

 https://sites.google.com/site/anthonycrastoorganicchemistry

/sites---my-own-on-the-net

 

 

THANKS AND REGARD'S
DR ANTHONY MELVIN CRASTO Ph.D

MOBILE-+91 9323115463
GLENMARK SCIENTIST , NAVIMUMBAI, INDIA
web link
https://sites.google.com/site/amcrasto/

 

 

 

19 Comments

Wed

25

Jan

2012

ANTHONY MELVIN CRASTO, Glenmark scientist helping millions

Congratulations! DR ANTHONY CRASTO

 

Your presentation titled

"Anthony Crasto Glenmark scientist, helping millions with websites"

 

has just crossed MILLION views.

15 Comments

Wed

25

Jan

2012

MY SITE ON PATENT RELATED INFORMATION

CLICK HERE TO ACCESSS

Anthony Crasto Patent Related Site

 

IS THE LINK TO MY PATENT RELATED INFORMATION

5 Comments